A study in Health Economics Review investigates the economic and equity impacts of expanding immunisation programs in low- and middle-income countries (LMICs), focusing on the cost-effectiveness of introducing new vaccines. The research highlights that while scaling up immunisation efforts requires significant investment, the long-term benefits—such as reduced disease burden, healthcare savings, and improved productivity—justify the costs. The study also emphasizes the importance of addressing equity gaps to ensure that vulnerable populations have access to vaccines. Policymakers and practitioners are encouraged to use economic evaluations to prioritize vaccine introductions and design strategies that maximize both health outcomes and equity.