The Linked Immunisation Action Network played a pivotal role in supporting Tunisia’s HPV vaccine introduction by leveraging peer-to-peer learning and cross-regional collaboration. Tunisia joined the network in 2023 during critical preparations for its school-based HPV rollout targeting 12-year-old girls. Participation in global workshops, including an Istanbul session with peers like the Philippines and Mongolia, provided reassurance and practical insights into implementation strategies. Key refinements to Tunisia’s plan included integrating religious leaders into communication efforts to address hesitancy—a lesson drawn from Jordan and Uzbekistan’s experiences. As a non-Gavi-eligible country, Tunisia also gained rare access to Alliance partners (e.g., Gavi, UNICEF, WHO), enhancing its understanding of technical support mechanisms and strengthening its funding application for vaccine procurement. Cross-regional engagements exposed Tunisia to diverse approaches, fostering innovation beyond regional norms and validating decisions like grade-based targeting over age-based cohorts. For EPI managers, Tunisia’s case underscores the value of structured peer learning in refining introduction strategies, the critical role of culturally tailored communication, and the benefits of global partnerships in navigating political and logistical challenges for sustainable vaccine rollout.