Greater attention and resources to low-income country vaccination programs over the last decade have resulted in tremendous gains in immunization coverage. But coverage rates have now stalled, calling for new approaches to overcoming enduring barriers to health care access. In this episode of Take as Directed, Dr. Orin Levine, Director of Vaccine Delivery for the Global Development Program at the Bill & Melinda Gates Foundation, discusses the potential of new technologies, strategies, and partnerships to improve vaccination rates and strengthen immunization systems even in the most difficult of settings.